NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF

摘要

Novel compounds effective in inhibiting the inflammatory symptom characteristic of nephritis and a nephritic remedy comprising any of the novel compounds as the active ingredient. The novel compounds are purine derivatives represented by general formula (I) (wherein R<1> represents a hydrocarbon group having up to 17 carbon atoms and R<2> represents a hydrocarbon group having up to 16 carbon atoms, provided that in each hydrocarbon group, at least one CH2 not directly bonded to the methylene group on the 2-position carbon atom or 7-position nitrogen atom of the purine ring has been replaced with any of carbonyl, sulfonyl, oxygen, and sulfur, and/or at least one CH not directly bonded to that methylene group has been replaced with any of nitrogen, carbon-halogeno, and C-CN) or pharmacologically acceptable salts thereof.