HYBRIDOMA SECRETING ANTIBODY TO RETROVIRUS INDUCING AIDS

摘要

PROBLEM TO BE SOLVED: To obtain the subject hybridoma capable of producing an antibody to HIV-2 inducing a lymphocyte disorder and AIDS(acquired immune deficiency syndrome) in a human being. SOLUTION: This hybridoma can secrete an antibody which is characterized by an ability of specifically recognizing an antigen selected from HIV-2 core proteins p12, p16, p26 and an HIV-2 envelope protein gp140, and the antigen has e.g. the amino acid sequence of formula I or formula II. The hybridoma is obtained by e.g. symbiotically cultivating an HIV-2-infected HUT78 cell and an HIV-2-infected normal human lymphocyte.