COMPOSITIONS AND METHODS FOR HOMOCONJUGATES OF ANTIBODIES WHICH INDUCE GROWTH ARREST OR APOPTOSIS OF TUMOR CELLS
摘要
This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
申请公布号
WO9902567(A2)
申请公布日期
1999.01.21
申请号
WO1998US14222
申请日期
1998.07.08
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;GHETIE, MARIA-ANA;UHR, JONATHAN, W.;VITETTA, ELLEN, S.
发明人
GHETIE, MARIA-ANA;UHR, JONATHAN, W.;VITETTA, ELLEN, S.