| 摘要 |
St. John's Wort has been indicated as a benefical supplement to human diet. It has been traditionally provided as an extract, tincture, tea or capsule form, usually administered in amount taken three times/day. It has been found that the manufacture of a tablet of this supplement material is a complex process, and that St. John's Wort extract is not amenable to wet tableting. A tablet which can be taken twice a day to provide a recommended supplemental level of St. John's Wort is described as comprising by weight of the tablet: 400 to 500 mg St. John's Wort extract as 57 to 75 % by weight of the tablet, 1.0-5.0 % by weight binder, 8-18 % by weight dissolution regulator, up to 30 % by weight filler, 0.2 to 5.0 % by weight glidant, and 0.5 to 2.5 % by weight lubricant/glidant. A process for manufacturing the tablet comprises the steps of: a) mixing components comprising 400 to 500 mg St. John's Wort extract as 57 to 75 % by weight of the tablet, 1.0-5.0 % by weight binder, 8-18 % by weight dissolution regulator, up to 10 % by weight filler, and less than a final proportion of glidant and lubricant/glidant of 0.2 to 5.0 % by weight glidant, and 0.5 to 2.5 % by weight lubricant/glidant to form a slug; b) breaking the slug down into particulates which can be subsequently compressed into a tablet; c) additing sufficent glidant and/or lubricant/glidant to form a composition with proportions of glidant and lubricant/glidant of 0.2 to 5.0 % by weight glidant, and 0.5 to 2.5 % by weight lubricant/glidant, and d) compressing the composition to form a tablet.
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