摘要 |
The present invention relates to a DNA molecule containing intron sequences and encoding a human protein which is, depending on the site of action, called Bile Salt-Stimulated Lipase (BSSL) or Carboxyl Ester Lipase (CEL). The DNA molecule is advantageously used in the production of recombinant human BSSL/CEL, preferably by means of production in transgenic non-human mammals. The recombinant human BSSL/CEL can be used as a constituent of infant formulas used for feeding infants as a substitute for human milk, or in the manufacture of medicaments against e.g. fat malabsorption, cystic fibrosis and chronic pancreatitis. |
申请人 |
AKTIEBOLAGET ASTRA |
发明人 |
BJURSELL, KARL, G.;CARLSSON, PETER, N. I.;LIDBERG, ULF, F. P.;NILSSON, JEANETTE, A.;ENERBACK, CURT, S. M.;HANSSON, STIG, L.;TORNELL, JAN, B. F. |