| 发明名称 |
SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF |
| 摘要 |
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
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| 申请公布号 |
CA2273083(A1) |
申请公布日期 |
1999.01.14 |
| 申请号 |
CA19972273083 |
申请日期 |
1997.12.03 |
| 申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
DANISHEFSKY, SAMUEL J.;SORENSEN, ERIK J.;SU, DAI-SHI;CHOU, TING-CHAO;KAMENECKA, TED;MENG, DONGFANG;BALOG, AARON;BERTINATO, PETER;SAVIN, KENNETH A. |
| 分类号 |
C07D277/06;A61K31/335;A61K31/337;A61K31/422;A61K31/425;A61K31/426;A61K31/429;A61K31/475;A61K31/70;A61K35/00;A61K45/06;C07C33/02;C07C43/12;C07C47/277;C07C69/007;C07C69/716;C07C69/738;C07C323/14;C07D263/32;C07D277/22;C07D277/24;C07D277/30;C07D313/00;C07D413/06;C07D417/06;C07D417/14;C07D493/04;C07F5/02;C07F7/18;(IPC1-7):C07D417/14;C07H17/02;C07H17/04;C07D405/06;C07D409/06;C07D209/08;C07D303/14;C07D405/14;C07D409/14;C07D413/14;C07D317/18;C07D317/26;C07D213/28;A61K31/34;C07D307/36;A61K31/40;A61K31/415;A61K31/42;A61K31/44;C07D233/54;C07D233/56;A61K31/585;C07D233/64;C07D211/82 |
主分类号 |
C07D277/06 |
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