TRANSDERMAL THERAPEUTIC SYSTEM (TTS) FOR ADMINISTERING SEXUAL STEROID HORMONES

摘要

The invention relates to a transdermal therapeutic system (TTS) for transcutaneal administration of sexual steroid hormones over long periods. The inventive system consists of a fixing aid and a polymethacrylate-based matrix containing steroid hormones. The invention also relates to a solvent-free, active substance-saving method for the production thereof. The inventive TTS is characterized by physical and chemical stability. It displays good adhesive properties over long periods of administration and releases high rates of active substance per surface unit through the skin. One advantage of the production process is that the active substances are subjected to as little thermal exposure as possible, thereby minimizing decomposition or disintegration reactions of said active substances.