METHODS FOR IMPROVED TARGETING OF ANTIBODY, ANTIBODY FRAGMENTS, HORMONESAND OTHER TARGETING AGENTS AND CONJUGATES THEREOF

摘要

Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delive ry to target cells of antibodies or fragments thereof or other receptor-mediated deliv ery system, such as peptide, specific for a population of cells of a mammal comprised steps of administering to said mammal an adequate dosage of blocking antibodies or fragme nts thereof or other receptor-mediated delivery system, such as peptide, and adminis tering to said mammal an effective dosage of said antibodies or fragments thereof or ot her receptore-mediated delivery system, such as peptide, specific for said populatio n of cells. In the preferred embodiment, the specific antibodies are monoclonal antib odies directed toward tumor-associated antigen in man.