| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel aminohydroxypropylpiperazine or its salt that is useful as a starting substance for a variety of pharmaceuticals. SOLUTION: This novel compound is an aminohydroxypropylpiperazine derivative of formula I (R1 is H, a protecting group; R2 and R3 are each H, a 1-4C alkyl, an aromatic group that may have substituents) or its salt, typically (S)-1-(2-hydroxy-3-phenylamino-propyl)-4-triphenylmethylpiperazine of formula II. A compound of formula I, for example, the compound of formula II is prepared by allowing (S)-N-(3-chloro-2-hydroxypropyl)aniline of formula III to react with 1-triphenylmethylpiperazine of formula IV in the presence of potassium carbonate and potassium iodide. |
