ALKALOIDS FROM MAPPIA FOETIDA, METHOD OF THEIR PREPARATION, USE THEREOF FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS, AND SAID PHARMACEUTICAL COMPOSITIONS THEM CONTAINING

摘要

Alkaloids of the general formula (I) present in different parts of Mappia foetida wherein R is H, foetidine 1 or R is OCH3, foetidine 2 with antitumor and antiviral activities. These alkaloids, when dissolved in water, are present in all parts of the plant Mappia foetida, out of which they are obtained and are camptothecin and 9- methoxycamptotecin precursors, i.e. alkaloids, whose pharmacodynamic properties as well as water-insolubility thereof are well-known. The particular water solubility of these alkaloids of formula (I) is of remarkable importance as it allows the parenteral administration without requiring derivatization.