发明名称 |
NOVEL DERIVATIVES OF SPIRO/2H-1-BENZOPYRANE-2,4'-PIPERIDINE/-4(3H)- ONE, ACID ADDITION SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>The invention relates to novel spiro(2H-1-benzopyran-2,4'-piperidine)-4(3H)-one derivatives of formula (I), wherein R stands for halogen, nitro group or a straight or branched chain C1-6 alkyl group, and their acid addition salts, as well as their quaternary salts of formula (Ia), wherein R and R' are the same or different and are identical to the meaning of said (above) R or can mean also hydrogen; and Z- represents one equivalent of an anion. The compounds of formulas (I) and (Ia) exert an improving effect on dementias of various pathological origin and accompanying symptoms thereof. Furthermore, the invention relates to a process for the preparation of compounds of formulas (I) and (Ia); to pharmaceutical compositions containing as active agents the above compounds of formulas (I) and (Ia); and to a method of treatment.</p> |
申请公布号 |
SI9720006(A) |
申请公布日期 |
1998.12.31 |
申请号 |
SI19970020006 |
申请日期 |
1997.04.03 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
HARSANYI KALMAN;SZABADKAI ISTVAN;BORZA ISTVAN;KARPATI EGON;KISS BELA;PELLIONISZ MARGIT;FARKAS SANDOR;HORVATH CSILLA;CSOMOR KATALIN;LAPIS ERZSEBET;LASZLOVSZKY ISTVAN;SZABO SANDOR;KIS-VARGA AGNES;LASZY JUDIT;GERE ANIKO |
分类号 |
C07D491/107;A61K31/438;A61K31/445;A61P25/28;C07D491/10;(IPC1-7):C07D491/107;A61K31/435 |
主分类号 |
C07D491/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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