发明名称 ANTIPROLIFERATIVE MEDICAMENTS CONTAINING FLAVANOLIGNANES WITH ANTAGONISTIC ACTIVITY ON THE ESTROGEN RECEPTORS OF TYPE II. AND METHOD FOR PRODUCING THEM
摘要 The invention relates to methods for preventing, inhibiting, or suppressing tumors by administering to a person in need of such treatment a therapeutically effective amount of one or more flavanolignanes, such as silymarin, silybin, silidianin, silicristin, dehydrosilybin, mixtures thereof, or extracts thereof as an antiproliferative. The invention further relates to the antitumor pharmaceutical composition includes a therapeutically effective amount of the flavanolignane selected from the group of silymarin, silybin, silidianin, silicristin, dehydrosilybin, and mixtures thereof, in combination with a different antitumor agent. In another embodiment, the pharmaceutical composition includes a therapeutically effective amount of a flavanolignane selected from the group of silidianin, silicristin, and mixtures thereof, with a pharmaceutically acceptable carrier or excipient. The compositions and method may be prepared or administered with different antitumoral agents for concurrent or sequential use for treating tumors, such as those typically found in the uterus, ovary, and breast.
申请公布号 HUT77966(A) 申请公布日期 1998.12.28
申请号 HU19980001682 申请日期 1995.10.10
申请人 INDENA S.P.A. 发明人 BOMBARDELLI,EZIO;MORAZZONI,PAOLO
分类号 C07D407/04;A61K31/335;A61K31/35;A61K31/352;A61K31/357;A61K31/366;A61K31/683;A61K36/00;A61K36/28;A61K36/48;A61K47/24;A61P13/02;A61P15/00;A61P35/00;A61P43/00 主分类号 C07D407/04
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