发明名称 |
SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING BROMO-SUBSTITUTED TRICYCLIC COMPOUNDS |
摘要 |
The invention relates to a process for preparing a compound of formula (I), comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR5R6 to obtain an amide; (b) reacting the amide with a compound of formula (3) in the presence of a strong base to obtain a compound of formula (4); (c) converting a compound of formula (4) to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula (7a) or (7b), respectively; (e) cyclizing a compound of formula (7a) or (7b); wherein R1-R7 are as defined in the specification.
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申请公布号 |
CA2293709(A1) |
申请公布日期 |
1998.12.23 |
申请号 |
CA19982293709 |
申请日期 |
1998.06.15 |
申请人 |
SCHERING CORPORATION |
发明人 |
WU, GUANG-ZHONG;CHEN, XING;WONG, YEE-SHING;POIRIER, MARC |
分类号 |
C07D401/04;(IPC1-7):C07D401/12 |
主分类号 |
C07D401/04 |
代理机构 |
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地址 |
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