发明名称 |
NOVEL AMINOOXYAMIDE TRICYCLIC INHIBITORS OF FARNESYLPROTEIN TRANSFERASE |
摘要 |
Novel aminooxyamide tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
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申请公布号 |
WO9857965(A1) |
申请公布日期 |
1998.12.23 |
申请号 |
WO1998US11510 |
申请日期 |
1998.06.15 |
申请人 |
SCHERING CORPORATION |
发明人 |
DOLL, RONALD, J.;LALWANI, TARIK |
分类号 |
A61K31/4545;A61P35/00;A61P43/00;C07D401/04;C07D401/14;C07D405/14;C07D409/14;(IPC1-7):C07D401/14;A61K31/47 |
主分类号 |
A61K31/4545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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