BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE

摘要

Novel compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO?-; R1 and R3¿ are the same or different and each represents halo; R?2 and R4¿ are the same or different and each is selected from H and halo, provided that at least one of R?2 and R4¿ is H; T is a substituent selected from SO¿2? R or (A); Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R?5)¿2; R5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.