Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where W means R1-A-B-D-C(R16), R1-A-B-D-C(R16)=C or cyclic system of the formula (II) being this system can comprise only one heteroatom among order N; Y means C= O, C= S; Z means N(R0); A means direct bond, C1-3-alkanediyl, -NR2-, -CO-; B means direct bond, C1-3-alkanediyl, phenylene, -NR2-, -CO-, -C(O)-NR2-, -NR2-C(O)-; D means direct bond, C1-3-alkanediyl, phenylene, -NR2-, -CO-, -CO-NR2-; E means direct bond, C1-3-alkanediyl; F means D; G means formula (III) ; L means N; R0 means hydrogen atom; R1 means or heterocycles. Compounds of the formula (I) show inhibitory activity on osteoclasts adhesion and therefore they can be used as inhibitors of bones resorption, growth inhibitors and tumors metastazing and so on, and as components of pharmaceutical composition. EFFECT: valuable medicinal properties of compounds. 5 cl, 38 ex