3-SUBSTITUTED 3,4 DIHYDRO-THIENO[2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME

摘要

The invention relates to 3-substituted 3,4 dihydro-thieno¢2, 3-d! pyrimidine derivatives of formula (I) wherein R1 and R2 mean a hydrogen atom or a C1-C4 alkyl group, R3 represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, C1-C4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups, said group being optionally anellated with a benzene nucleus which is optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, hydroxy, trifluoromethyl, C1-C4 alkoxy, amino, cyano or nitro groups and may contain optionally 1 nitrogen atom, or with a 5 or 6-membered ring which may contain 1-2 oxygen atoms, A represents NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z represents a nitrogen atom, carbon atom or CH and the bond between Y and Z can also be a double bond, and n is the number 2, 3 or 4. The invention also relates to the physiologically compatible salts of the inventive 3-substituted 3,4 dihydro-thieno¢2,3-d! pyrimidine derivatives.