Pentaerythritol derivatives

摘要

Pentaerythritol derivatives of formula (I), (III), (VI), (VII), (VIII) and (XV) and their salts are new: (O2NOCH2)mC(CH2OH)n(CH2COR<1>)o(COR<1>)p (I) (O2NOCH2)mC(CH2OH)n(CH2COR<3>)o(COR<3>)p (III) (O2NOCH2)mC(CH2OH)n(CH2COR<5>)o(COR<5>)p (VI) (HOCH2)q(O2NOCH2)rC(CH2OR<6>)s (VII) (O2NOCH2)mC(CH2OH)n(CH2COR<7>)o(COR<7>)p (VIII) (HOCH2)q(O2NOCH2)rC(CH2OR<14>)s (XV) R<1> = a group of formula (II); R<3> = a group of formula (IV); R<5> = (2-carboxyphenyl)oxy or (2-alkoxycarbonylphenyl)oxy; R<6> = salicyloyl or acetylsalicyloyl; R<7> = a group of formula (IX); R<14> = acyl radical of a compound of formula (X), (XI), (XII), (XIII) or (XIV) (sic); R<2> = 1-20C alkyl, especially Me, Et, n-Pr, i-Pr, n-butyl, n-pentyl, n-hexyl, n-octyl, benzyl, cyclohexylmethyl, 4-chlorobenzyl, 4-nitrobenzyl, 2-phenylethyl, 3-phenylpropyl, 3-cyclohexylpropyl, 3-phthalimidylpropyl, 1-naphthylmethyl, cinnamyl, 5-ethoxycarbonylbutyl, 3-aminopropyl, -(CH2)3CH(NHCOCH3)COOH, -(CH2)3CH(NHCOCH3)COOCH3 or 1,6-hexane-bis; R<8>, R<9> = 1-6C alkyl or R<8>+R<9> = 1-6C alkylene; R<10> = OH, NHR<8>R<9>, 1-6C alkoxy, (2-carboxyphenyl)oxy, (2-alkoxycarbonylphenyl)oxy, (1-carboxymethyl-2-dialkylamino)ethoxy, (1-carboxymethyl-2-trialkylammonium)ethoxy, (1-alkoxycarbonylmethyl-2-dialkylamino)ethoxy or (1-alkoxycarbonylmethyl-2-trialkylammonium)ethoxy; m, p, r, s /-1; m+n+o+p = 4; q+r+s = 4. Also claimed are compounds of formula (V), (X), (XI) and (XIV) and their salts. R<4> = H, 1-6C alkanoyl, salicyloyl or acetylsalicyloyl; R<11> = NO2 and for (XV) H, 1-6C alkanoyl, salicyloyl, acetylsalicyloyl or -CO-CH2CH(OH)-CH2-NR<8>R<9>; R<12> = 1-6C alkyl, especially Me, Et or n-Pr; R<13> = H or 1-6C alkyl; X = an anion or absent if COR<10> is capable of forming an inner salt.