| 摘要 |
Novel halo-N-substituted urea compounds and pharmaceutical compositions of formula (1.0) or a pharmaceutically acceptable salt or solvate theroef, are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human. |
