| 发明名称 |
Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II |
| 摘要 |
The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria.
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| 申请公布号 |
US5849691(A) |
申请公布日期 |
1998.12.15 |
| 申请号 |
US19960603737 |
申请日期 |
1996.02.20 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MAJER, PAVEL;COLLINS, JACK;GULNIK, SERGEI;ERICKSON, JOHN |
| 分类号 |
C07D317/60;A61K31/165;A61K31/195;A61K31/215;A61K31/357;A61K31/36;A61K31/44;A61K38/00;A61P25/28;A61P33/02;A61P35/00;C07C229/36;C07D213/30;C07D255/02;C07K5/02;C07K5/027;C07K7/02;C07K7/56;C07K14/81;(IPC1-7):A61K38/00;C07K5/12 |
主分类号 |
C07D317/60 |
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