A METHOD OF INACTIVATING A LIPID-ENVELOPED VIRUS IN A THERAPEUTIC SOLUTION

摘要

Lipid-enveloped viruses present in purified biologically active protein products obtained from blood or cell culture systems can be inactivated by contacting the products with caprylic acid at a non-ionized concentration, pH, temperature and ionic environment sufficient to inactivate the viruses without adversely precipitating or affecting the biological activity of the protein products.