Inhibition of viruses by antisense oligomers capable of binding to polypurine rich tract of single-stranded RNA or RNA-DNA hybrids

摘要

The present invention provides methods of inhibiting a virus with which a vertebrate is infected and which replicates via an RNA template comprising the administration of an antisense or triplex-forming oligonucleotide or a derivative thereof capable of binding to a polypurine-rich tract in a region of single-stranded RNA or RNA-DNA hybrid, respectively. Chimeric oligonucleotides capable of forming triplex structures with single-stranded nucleic acids are also disclosed.