PROTECTIVE COMPOSITIONS

摘要

A composition for use in protecting against alkylating agents in particular sulphur mustard; said composition comprising a compound of the formula (I): H2NCH(COOR<2>)CH2CH2CONHCH(CH2SH)CONHCH2COOR<1>, or a salt thereof; where R<1> and R<2> are independently selected from hydrogen or an optionally substitued hydrocarbyl group having at least three carbon atoms; provided that R<1> and R<2> are not both hydrogen, is described. Preferred compounds of the formula (I) are monoisopropylglutathione ester (MIPE) or diisopropylglutathione ester (DIPE). Compositions are suitably formulated as barrier creams and/or liquids for application by nasal spray or inhaler. Method of protecting living tissue from the effects of alkylating agent such as sulphur mustard are also described and claimed.