PROCESS FOR OBTAINING QUINAPRYL HYDROCHLORIDE AND SOLVATES USEFUL FOR ISOLATING AND PURIFYING QUINAPRYL HYDROCHLORIDE

摘要

The process for obtaining quinapryl hydrochloride (I) comprises the following steps: a) hydrogenolysis of quinapryl benzyl ester (II) by treatment in an alcoholic solvent, with hydrochloric acid or with a solution of hydrogen chloride in isopropanol and hydrogenation; b) removing the solvent; c) addition of toluen to precipitate the quinapryl hydrochloride as toluen solvate; d) treating said solvate with a solvent of class 3 to form a solvate of quinapryl hydrochloride from which it can be dry-removed without degradation; and e) drying the solvate of step b) to yield (I). These solvates are useful to isolate and purify (I), an antihypertensive agent.