NITROGENOUS HETEROCYCLIC COMPOUNDS AND HYPERLIPEMIA REMEDY CONTAINING THE SAME

摘要

Compounds represented by general formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds inhibit the biosynthesis of triglycerides in the liver and also inhibit the secretion of lipoproteins containing apolipoprotein B from the liver. They are hence useful for the prevention/treatment of hyperlipemia (especially hyper-VLDL-emia) and diseases caused thereby, such as arteriosclerotic diseases, e.g., myocardial infarct, and pancreatitis. Wherein A represents -CR<1>R<2>-(CH2)i- (wherein R<1> and R<2> each represents hydrogen or alkyl), -CH=CH-, -O-CH2-, or -S(O)j-CH2-; B represents hydrogen or halogen; X represents -CR<3>R<4>R<5>, -NR<6>R<7>, -(CH2-CH=C(CH3)-CH2)p-CH2CH=C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaryl; Y represents -(CH2)q-, -CH=CH-, -NR<8>-, oxygen, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents -CH=CH- or a bond; and M represents hydrogen, alkyl, cycloalkyl, phenyl, heterocycle, biphenyl, or diphenymethyl.