发明名称 |
Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes |
摘要 |
Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula <IMAGE> (I) where R1 is diaminocycloalkyl, and R2 and R3 each have the formula <IMAGE> where R4, R5, and R6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms, into a complex having the formulaR1-Pt-X2where X is halogen.
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申请公布号 |
US5843475(A) |
申请公布日期 |
1998.12.01 |
申请号 |
US19960764095 |
申请日期 |
1996.12.06 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
PEREZ-SOLER, ROMAN;KHOKHAR, ABDUL R. |
分类号 |
A61K9/127;A61K31/282;A61P35/00;A61P43/00;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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