Epoxysuccinic acid derivatives

摘要

PCT No. PCT/JP96/00889 Sec. 371 Date Sep. 29, 1997 Sec. 102(e) Date Sep. 29, 1997 PCT Filed Apr. 1, 1996 PCT Pub. No. WO96/30354 PCT Pub. Date Oct. 3, 1996An epoxysuccinic acid derivative having the following formula: <IMAGE> [wherein R1 is hydrogen, alkyl, aryl, or aralkyl; each of R2 and R3 independently is aryl, aralkyl or alkyl; X is -O- or -NR4-; and R4 is hydrogen, alkyl, or aralkyl] is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.