发明名称 |
Differential inactivation of nucleic acids by chemical modification |
摘要 |
Disclosed herein is the method for dramatically reducing cytotoxicity of viral vectors such as Herpes simplex viral while retaining gene expression. The method of the invention virtually eliminates the concern of possible recombination during virus propagation and contamination of wild-type virus and virus stock. The invention comprises use of photochemical crosslinking causing differential inactivation of viruses.
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申请公布号 |
US5843459(A) |
申请公布日期 |
1998.12.01 |
申请号 |
US19960587725 |
申请日期 |
1996.01.19 |
申请人 |
HUMAN GENE THERAPY RESEARCH INSTITUTE |
发明人 |
WANG, SUMING;LINK, JR., CHARLES J. |
分类号 |
C12N15/869;(IPC1-7):C12Q1/70;A61K39/245 |
主分类号 |
C12N15/869 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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