| 摘要 |
The present invention relates to a process for the preparation of particles each comprising an excipient forming a matrix and at least one active ingredient uniformly distributed in the mass of said matrix, said process, which comprises the operations of extrusion and then lyophilization, being characterized in that it comprises the steps consisting of (1.) the preparation of a homogeneous mixture from (a) at least one active ingredient, (b) a physiologically acceptable hydrophilic excipient, and (c) water to give a pasty mixture with a viscosity below 1 Pa.s, measured at room temperature (15 DEG -20 DEG C.); (2.) the extrusion of the resulting homogeneous mixture and the cutting of the extrudate to give moist particles; (3.) the freezing of the resulting particles as they fall under gravity through a stream of inert gas at a temperature below 0 DEG C.; and (4.) the freeze drying of said particles.
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