| 摘要 |
<p>PCT No. PCT/EP94/03866 Sec. 371 Date Aug. 5, 1996 Sec. 102(e) Date Aug. 5, 1996 PCT Filed Nov. 23, 1994 PCT Pub. No. WO95/15158 PCT Pub. Date Jun. 8, 1995An active substance-containing patch for the controlled release of active substances, comprising a backing layer, an adjoining active substance-containing reservoir layer softening at body temperature, a membrane controlling the active substance release, a pressure-sensitive adhesive device permitting fixation of the patch to the skin, and a removable protective layer, is characterized by the fact that the reservoir layer which softens at body temperature is spaced away from the controlling membrane by means of a device made of a material impermeable to the active substance which extends all over the mutually facing surfaces of the reservoir and the membrane and which has at least one passage for the reservoir layer which softens at body temperature.</p> |
