A process producing a pharmaceutical lozenge formulation comprising the steps of: 1) granulating a mixture of flurbiprofen and a bulking agent with a solution of a binding agent in a polar solvent to form granules; 2) melting a lozenge-forming composition; 3) mixing the granules with the molten lozenge-forming composition; 4) forming the resulting mixture into lozenges each containing a therapeutically effective amount of flurbiprofen.
申请公布号
WO9852539(A1)
申请公布日期
1998.11.26
申请号
WO1998EP03167
申请日期
1998.05.20
申请人
THE BOOTS COMPANY PLC;DAY, ANDREW;JONES, HUW, LYN;SMITH, CARL, SIMON