| 摘要 |
<p>A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed: <CHEM> wherein R<1> represents a hydroxyl group, alkoxy, alkylcarbonyloxy, or aralkyloxy; R<2> represents alkyl, - CH2OR<5>, wherein R<5> represents a hydrogen atom, alkyl, aralkyl, or alkylcarbonyl, formyl, -COOR<6>, wherein R<6> represents a hydrogen atom or alkyl, or -CH2N(R<7>)R<8>; or R<1> and R<2> combine with each other to form -O-CR<9)<R<10>)-OCH2-, wherein R<9> and R<10>, which may be the same or different, represent a hydrogen atom, alkyl, or aryl; R<3> and R<4>, which may be the same or different, represent a hydrogen atom, a hydroxyl group, alkyl, hydroxyalkyl, formyl, -COOR<11>, wherein R<11> represents a hydrogen atom or alkyl, or -OR<12>, wherein R<12> represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl, or arylalkenylcarbonyl which may be optionally substituted; or R<3> and R<4> combine with each other to form a methylene group; and @ represents a single or double bond, provided that, when @ represents a double bond, R<4> is absent.</p> |
