发明名称 |
NUCLEIC ACID BINDING PROTEINS |
摘要 |
The invention provides a method for preparing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding to a nucleic acid quadruplet in a target nucleic acid sequence, wherein binding to base 4 of the quadruplet by an alpha -helical zinc finger nucleic acid binding motif in the protein is determined as follows: if base 4 in the quadruplet is A, then position +6 in the alpha -helix is Glu, Asn or Val; if base 4 in the quadruplet is C, then position +6 in the alpha -helix is Ser, Thr, Val, Ala, Glu or Asn. |
申请公布号 |
WO9853058(A1) |
申请公布日期 |
1998.11.26 |
申请号 |
WO1998GB01512 |
申请日期 |
1998.05.26 |
申请人 |
MEDICAL RESEARCH COUNCIL;CHOO, YEN;KLUG, AARON;ISALAN, MARK |
发明人 |
CHOO, YEN;KLUG, AARON;ISALAN, MARK |
分类号 |
C12N15/09;C07K1/04;C07K14/47;C12N1/21;C12N15/10;C12P21/02;C12Q1/68;C40B40/02;(IPC1-7):C12N15/10;C12N15/12;C12N15/62;A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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