发明名称 |
Genetically engineered animals containing null mutations in the neurofilament genes |
摘要 |
The present invention provides for genetically engineered non-human animals, including but not limited to mice, which lack one or more endogenous neurofilament gene. Human neurofilament genes may be introduced into such genetically non-human animals (referred to hereafter as "knockout animals") to produce improved models of the physiology of human neurofilament proteins which may be used to study human neurofilament-associated neurodegenerative conditions. |
申请公布号 |
AU7470598(A) |
申请公布日期 |
1998.11.24 |
申请号 |
AU19980074705 |
申请日期 |
1998.05.01 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YO |
发明人 |
ROBERT A LAZZARINI;GREGORY ELDER |
分类号 |
A01K67/027;A61K49/00;C07K14/47;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|