发明名称 |
PEPTIDES WHICH ENHANCE TRANSPORT OF AN ACTIVE AGENT ACROSS TISSUES AND COMPOSITIONS AND METHODS OF USING THE SAME |
摘要 |
Targeting agents that are capable of permitting or facilitating transport of an active agent through a human or animal gastro-intestinal tissue. These targeting agents are peptides or their derivatives (e.g., fragments) and peptidomimetics thereof, and the nucleotide sequences coding for the peptides and derivatives. The targeting agents have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Therapeutic methods of administration, pharmaceutical compositions and formulations based on the targeting agent peptides are also provided. Preferably, the active agent is a drug or drug-containing nano- or microparticle.
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申请公布号 |
CA2290071(A1) |
申请公布日期 |
1998.11.19 |
申请号 |
CA19982290071 |
申请日期 |
1998.05.15 |
申请人 |
ELAN CORPORATION, PLC;CYTOGEN CORPORATION |
发明人 |
ALVAREZ, VERNON LEON;SEVESO, MICHELA;O'MAHONY, DANIEL JOSEPH |
分类号 |
C12N15/09;A61K9/16;A61K9/50;A61K9/51;A61K38/00;A61K47/48;A61K48/00;A61P5/48;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C12N15/10;C40B40/02;G01N33/68;(IPC1-7):A61K47/42;C07K14/00;A61K38/16 |
主分类号 |
C12N15/09 |
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