发明名称 |
FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND OF A CALCIUM CHANNEL ANTAGONIST, METHOD FOR PREPARATION AND USETHEREOF IN THE TREATMENT OF CARDIOVASCULARILLNESSES |
摘要 |
FIXED-DOSE ASSOCIATION OF AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND OF A CALCIUM CHANNEL ANTAGONIST, METHOD FOR PREPARATION AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR ILLNESSES Comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitrendipine or a pharmaceutically acceptable salt thereof and in that it is administered in single-dose gallenic form. The method comprises: (a) dissolving enalapril maleate in water with an inorganic salt; (b) mixing the micronized nitrendipine with a fraction of he disintegrating excipients, the wetting agent, the fragmentary diluting agent, the agglutinating agent, and the plastic diluting agent, previously sieved; (c) granulating the products homogenized in section (b) with the solution obtained in section (a); (d) drying the granulated mass; (e) incorporating the lubricating agent, and the remaining fraction of the disintegrating excipients and homogenizing the calibrated granulate; (f) compressing the granulate. Use of said association for the manufacture of a medicament for the treatment of illnesses of the cardiovascular system.
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申请公布号 |
CA2234899(A1) |
申请公布日期 |
1998.11.13 |
申请号 |
CA19982234899 |
申请日期 |
1998.05.12 |
申请人 |
VITA-INVEST, S.A. |
发明人 |
MICHETO ESCUDE, LUIS MANUEL;DELGADILLO DUARTE, JOAQUIN;CANOVAS SOLER, PEDRO |
分类号 |
A61K31/40;A61K9/14;A61K9/16;A61K9/48;A61K31/401;A61K31/44;A61K31/4422;A61K31/455;A61K38/00;A61K38/55;A61K47/12;A61K47/26;A61K47/32;A61K47/38;A61P9/00;A61P9/12;A61P43/00;(IPC1-7):A61K38/05 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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