COMPOSITION AND METHOD FOR TREATMENT OF HELICOBACTER PYLORI INFECTION

摘要

The present invention relates to a composition and a method for treating Helicobacter pylori (H. pylori) infection in an animal or human, comprising a membrane-permeant urease inhibitor (UI) and a pH adjusting agent (B) sufficient to maintain a low pH in the bacterial microenvironment. More particularly, the present invention relates to a membrane-permeant urease inhibitor (UI) and a pH adjusting agent (B) effective to maintain a pH below approximately 6.0 in the bacterial microenvironment for a period of time sufficient to be detrimental to the growth and survival of the H. pylori. Methods of making UI-B and methods of using UI-B are also disclosed.