发明名称 |
POTENTIATION OF THE IMMUNE RESPONSE THROUGH DELIVERY OF COMPOUNDS BINDING A CYTOPLASMIC DIPEPTIDASE |
摘要 |
A method for stimulating proliferation of T-cells containing cytoplasmic post-prolyl dipeptidase activity; the method, in one aspect, involves contacting the T-cells with an organic compound at a concentration below 10<-8>M, wherein the compound is characterized in that: (a) it is capable of crossing the membrane of T-cells to enter the cytoplasm, (b) it binds to the dipeptidase activity at a concentration of below 10<-8>M, and thus (c) stimulates proliferation of the T-cells at that concentration.
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申请公布号 |
WO9850066(A1) |
申请公布日期 |
1998.11.12 |
申请号 |
WO1998US08838 |
申请日期 |
1998.04.30 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
HUBER, BRIGITTE, T.;SCHMITZ, TRACY;UNDERWOOD, ROBERT |
分类号 |
A61K45/00;A61K38/55;A61K39/39;A61P31/18;A61P37/04;C07K14/155;C07K14/73;(IPC1-7):A61K38/55;G01N33/50 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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