发明名称 Antifungal composition with enhanced bioavailability
摘要 A pharmaceutical composition comprising: i) an antifungal agent which is (-)-(2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxypropyl]-3H-1,2,4-triazol-3-one; ii) at least one non-ionic surfactant; and iii) a diluent. The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
申请公布号 US5834472(A) 申请公布日期 1998.11.10
申请号 US19970861250 申请日期 1997.05.21
申请人 SCHERING CORPORATION 发明人 SANGEKAR, SURENDRA A.;VADINO, WINSTON A.;LEE, PING I.
分类号 A61K31/496;(IPC1-7):A61K31/50;A61K31/495 主分类号 A61K31/496
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