发明名称 |
Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
摘要 |
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pKa of about 8.0 or greater, an effective amount of a penetration enhancer consisting essentially of triacetin, and a polymer layer preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.
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申请公布号 |
US5834010(A) |
申请公布日期 |
1998.11.10 |
申请号 |
US19970775367 |
申请日期 |
1997.01.03 |
申请人 |
THERATECH, INC. |
发明人 |
QUAN, DANYI;DESHPANDAY, NINAD A.;VENKATESHWARAN, SRINIVASAN;EBERT, CHARLES D. |
分类号 |
A61K9/00;A61K9/70;A61K31/137;A61K31/138;A61K31/167;A61K31/216;A61K31/404;A61K31/4458;A61K31/46;A61K31/485;A61K31/5415;A61K31/55;A61K47/10;A61K47/14;A61K47/30;A61K47/32;A61P9/00;A61P9/06;A61P21/02;A61P23/02;A61P25/04;A61P25/24;A61P25/26;A61P27/02;(IPC1-7):A61F13/02 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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