Devices and method for freezing of tissues. Devices comprise a cryosurgical probe that can be very slim with diameter up to a fraction of a millimeter for very focal freezing application, and an insulating canula for adjusting freeze zone. A cryosurgical probe with solid and liquid cold sources, wherein the solid cold source forms the portion of the probe inserted to tissue for thermal exchange while the liquid cold source maintains the operating temperature of said solid cold source. Method for rupturing targeted cells during freezing while minimizing freezing of nearby tissues and vasculatures.
