发明名称 |
Modified factor VII |
摘要 |
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders, including platelet deposition, vascular thrombosis, ischemic reperfusion, acute closure of a coronary artery, vascular restenosis secondary to balloon angioplasty, endarterectomy, reductive atherectomy, stent placement, laser therapy or rotablation.
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申请公布号 |
US5833982(A) |
申请公布日期 |
1998.11.10 |
申请号 |
US19960660289 |
申请日期 |
1996.06.07 |
申请人 |
ZYMOGENETICS, INC.;NOVO NORDISK A/S |
发明人 |
BERKNER, KATHLEEN L.;PETERSEN, LARS CHRISTIAN;HART, CHARLES E.;HEDNER, ULLA;BREGENGAARD, CLAUS |
分类号 |
A61K38/55;A61K38/00;A61K38/16;A61K38/36;A61K38/43;A61K38/48;A61K38/49;C07K14/745;C12N9/64;(IPC1-7):A61K38/48;A61K35/14;C12N9/48 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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