| 发明名称 |
Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III |
| 摘要 |
<p>10-Deacetylbaccatin III is selectively acylated to baccatin III and derivatives thereof in high yield with anhydrides (e.g. acetic anhydride), catalysed by Lewis acids. Extremely effective catalysts in this reaction are compounds of the formula MLx wherein M is a rare earth metal and L is a anion, preferably a strong electron withdrawing counterion such as triflate.</p> |
| 申请公布号 |
EP0875508(A1) |
申请公布日期 |
1998.11.04 |
| 申请号 |
EP19970201315 |
申请日期 |
1997.05.02 |
| 申请人 |
PHARMACHEMIE B.V. |
发明人 |
DAMEN, ERIC WILHELMUS PETRUS;SCHEEREN, JOHAN WILHELM;DE VOS, DICK |
| 分类号 |
A61P35/00;A61K31/335;A61K31/337;C07B61/00;C07D305/14;(IPC1-7):C07D305/14 |
主分类号 |
A61P35/00 |
| 代理机构 |
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