Quinoline and quinazoline compounds useful in therapy

摘要

Compounds of formula I, <CHEM> wherein R<1> represents C1-4 alkoxy optionally substituted by one or more fluorine atoms, R<2> represents an aryl group or a heteroaryl group, optionally substituted by C1-4 alkyl or SO2NH2; R<3> represents a 4-, 5-, 6-, or 7-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing at least one heteroatom selected from N, O and S, the ring system as a whole being optionally substituted, X represents CH or N; and L is absent, or represents a cyclic group of formula Ia, <CHEM> or represents a chain of formula Ib, <CHEM> and pharmaceutically acceptable salts thereof, are useful in the treatment of a variety of disorders including benign prostatic hyperplasia.