Process for preparing deuterium tagged compounds

摘要

A process for the preparation of organic and inorganic deuterium-tagged compounds is disclosed. The process comprises heating a deuterium oxide-solution of an organic or inorganic compound, the solution having a pH of from about 10 to about 1 to a temperature and pressure so that a supercritical reaction mass forms and one or more deuterium atoms of the deuterium oxide solvent exchanges with one or more protons of the organic or inorganic compound. After cooling the reaction solution formed from the supercritical reaction, the organic or inorganic deuterium-tagged compound is separated.