Peptides reactive with multiple sclerosis antibodies

摘要

Peptides that specifically react with antibodies of multiple sclerosis (MS) patients and have the following amino acid sequences are new: (1) Gln Gln Ala Val; (2) Thr Gly Arg Pro; (3) Leu Gln Gln Ala Val Phe; (4) Ser Thr Gly Arg Pro Leu; (5) Arg Leu Val Leu Val Pro; (6) Phe Leu Glu Asn Gly Val; (7) Lys Gly Thr Ser Leu Ser; (8) Leu Ala Val Arg His Asp; (9) Thr Phe Asp Arg Arg Ile; (10) Asn Ala Cys Tyr Val Asp Leu Phe Leu Gly Ala Ser Val Cys Pro; (11) Ser Ser Ala Lys Ser His Cys Tyr Ala Phe Cys Ser Gly Leu Pro; (12) Met Pro Val Ser Arg Leu Cys Ile Glu Leu Asp Trp Cys Pro Pro; (13) Phe Cys Pro Pro Ile Leu Pro Tyr Ser Ala Trp Cys Pro Val Pro; (14) Glu Pro Met Thr Pro His Gln Trp Ile Thr Leu Tyr Arg Ser Tyr; (15) Asp Thr Pro Tyr Pro Trp Gly Trp Leu Leu Asp Glu Gly Tyr Asp; (16) Ser Arg Gly Ser His Glu Trp Ala Val Leu Phe Arg Phe Tyr Tyr; (17) Gln Ser Pro Leu Glu Asp Arg Ile Leu Arg Phe Leu Ser Pro Pro; (18) His Cys Arg Lys Val Thr Gly Ser Asp Tyr Leu Leu Cys Gly Leu. Also claimed are "equivalents" of the above peptides, including those based on the homology of peptide (11) to a foot-and-mouth disease SAT3 protein sequence and the homology of peptide (13) to a feline sarcoma virus (FSV) p30/p10/5'v-fsm sequence. Also claimed are polynucleotides encoding the peptides.