2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT .BETA.-LACTAMASE INHIBITORS

摘要

This invention relates to novel 2-oxo-1-azetidine sulfonic acid derivatives of formula (I) which are of value for use in combination with .beta.-lactam antibiotics to increase their effectiveness against infections caused by .beta.-lactamase producing bacteria. In said formula, (I) R1 is a 5-membered heterocyclic ring esp. thiophene, 2-amino thiazole. R2 is a moiety containing hydroxypyridone or N-hydroxypyridone.