THERAPEUTIC ANTIOXIDANTS FOR ALZHEIMER'S DISEASE

摘要

The invention discloses therapeutic antioxidant compounds of formula (I), (II), (III); wherein Class I Compounds: X = S or O, Y = OR1 or SR1, R1 = hydrogen, lower alkyl, W and V selected from the following = OH, NO2, CF3, halogen, OR2, CONHR2 NHCOR2 (R2 = H, lower alkyl), CN, H, lower alkyl, -(CH2)nSH, -(CH2)nCONH(CH2)mSH, -(CH2)nNHCO(CH2)mSH, (a); Class II and III compounds: X = S or O, Y = OR1 or SR1, R and R1 selected from hydrogen, lower alkyl, -(CH2)nSH, -(CH2)nCONH(CH2)mSH, -(CH2)nNHCO(CH2)mSH, (a); additionally for class III compounds: P and Q selected from hydrogen, lower alkyl, aminomethyl, hydroxymethyl, CH2OCOR2, CH2NHCOR2 R2 = hydrogen, lower alkyl), -(CH2)nSH, -(CH2)nCONH(CH2)mSH, -(CH2)nNHCO(CH2)mSH, (a), wherein in general X = S or O and Y = OR1 or SR1. Compounds of the invention may be used as pharmaceuticals for therapy and prophylaxis of neurodegenerative disease such as Alzheimer's disease.