| 发明名称 |
Humanes rekombinantes Interferon-beta mit verbesserter Löslichkeit |
| 摘要 |
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu (5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) and Phe(156) are exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.
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| 申请公布号 |
DE19717864(A1) |
申请公布日期 |
1998.10.29 |
| 申请号 |
DE1997117864 |
申请日期 |
1997.04.23 |
| 申请人 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V., 80636 MUENCHEN, DE |
发明人 |
SCHNEIDER-FRESENIUS, CHRISTIAN, 30177 HANNOVER, DE;OTTO, BERND, DR., 30659 HANNOVER, DE;WASCHUETZA, GERO, DR., 38536 MEINERSEN, DE |
| 分类号 |
C12N15/09;A61K38/00;A61K38/21;A61P25/00;A61P31/12;C07K14/565;C12N15/22;C12P21/02;(IPC1-7):C07K14/555 |
主分类号 |
C12N15/09 |
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