PRODUCTION OF FLUORINE-CONTAINING COMPOUND

摘要

PROBLEM TO BE SOLVED: To simply obtain a fluorine-containing compound by reacting anα- perfluoroalkylated alcohol with a Broensted acid in an aprotic solvent. SOLUTION: A perfluoroalkylsulfonic acid ester or perfluoroarylsulfonic acid ester of anα-perfluoroalkylated alcohol of the formula R<1> R<2> Rf<1> C-OSO2 Rf<2> [R<1> and R<2> are each H, an alkyl, an aromatic, an aralkyl, an alkenyl or an alkynyl or R<1> and R<2> together may form a ring; Rf<1> and Rf<2> are each a perfluoroalkyl or a perfluoro aromatic] is reacted with a Broensted acid of the formula M m Q n [M is a metal ion or polyatomic cation; Q is a conjugated base of the Broensted acid QHy ; (x), (y), (m) and (n) are each an integer satisfying the formula xm=yn] in a solvent such as DMF at -100 to 200 deg.C to provide the objective fluorine-containing compound of the formula (R<1> R<2> Rf<1> C-)y Q (Q is a Broensted acid residue). The compound can be utilized as a synthetic intermediate for medicines and agrochemicals such as aticancer agents and enzyme inhibitors and functional materials such as ferroelectric liquid crystals.